How our principles helped define AlphaFold's release – DeepMind

Putting our mission of solving intelligence to advance science and benefit humanity into practice comes with crucial responsibilities. To help create a positive impact for society, we must proactively evaluate the ethical implications of our research and its applications in a rigorous and careful way. We also know that every new technology has the potential for harm, and we take long and short term risks seriously. We’ve built our foundations on pioneering responsibly from the outset – especially focused on responsible governance, research, and impact.
This starts with setting clear principles that help realise the benefits of artificial intelligence (AI), while mitigating its risks and potential negative outcomes. Pioneering responsibly is a collective effort, which is why we’ve contributed to many AI community standards, such as those developed by Google, the Partnership on AI, and the OECD (Organisation for Economic Co-operation and Development).
Our Operating Principles have come to define both our commitment to prioritising widespread benefit, as well as the areas of research and applications we refuse to pursue. These principles have been at the heart of our decision making since DeepMind was founded, and continue to be refined as the AI landscape changes and grows. They are designed for our role as a research-driven science company and consistent with Google’s AI Principles.
Written principles are only part of the puzzle – how they’re put into practice is key. For complex research being done at the frontiers of AI, this brings significant challenges: How can researchers predict potential benefits and harms that may occur in the distant future? How can we develop better ethical foresight from a wide range of perspectives? And what does it take to explore hard questions alongside scientific progress in realtime to prevent negative consequences?
We’ve spent many years developing our own skills and processes for responsible governance, research, and impact across DeepMind, from creating internal toolkits and publishing papers on sociotechnical issues to supporting efforts to increase deliberation and foresight across the AI field. To help empower DeepMind teams to pioneer responsibly and safeguard against harm, our interdisciplinary Institutional Review Committee (IRC) meets every two weeks to carefully evaluate DeepMind projects, papers, and collaborations.
Pioneering responsibly is a collective muscle, and every project is an opportunity to strengthen our joint skills and understanding. We’ve carefully designed our review process to include rotating experts from a wide range of disciplines, with machine learning researchers, ethicists, and safety experts sitting alongside engineers, security experts, policy professionals, and more. These diverse voices regularly identify ways to expand the benefits of our technologies, suggest areas of research and applications to change or slow, and highlight projects where further external consultation is needed.
While we’ve made a lot of progress, many aspects of this lie in uncharted territory. We won’t get it right every time and are committed to continual learning and iteration. We hope sharing our current process will be useful to others working on responsible AI, and encourage feedback as we continue to learn, which is why we’ve detailed reflections and lessons from one of our most complex and rewarding projects: AlphaFold. Our AlphaFold AI system solved the 50-year-old challenge of protein structure prediction – and we’ve been thrilled to see scientists using it to accelerate progress in fields such as sustainability, food security, drug discovery, and fundamental human biology since releasing it to the wider community last year.


Our team of machine learning researchers, biologists, and engineers had long seen the protein-folding problem as a remarkable and unique opportunity for AI-learning systems to create a significant impact. In this arena, there are standard measures of success or failure, and a clear boundary to what the AI system needs to do to help scientists in their work – predict the three-dimensional structure of a protein. And, as with many biological systems, protein folding is far too complex for anyone to write the rules for how it works. But an AI system might be able to learn those rules for itself. 
Another important factor was the biennial assessment, known as CASP (the Critical Assessment of protein Structure Prediction), which was founded by Professor John Moult and Professor Krzysztof Fidelis. With each gathering, CASP provides an exceptionally robust assessment of progress, requiring participants to predict structures that have only recently been discovered through experiments. The results are a great catalyst for ambitious research and scientific excellence. 


As we prepared for the CASP assessment in 2020, we realised that AlphaFold showed great potential for solving the challenge at hand. We spent considerable time and effort analysing the practical implications, questioning: How could AlphaFold accelerate biological research and applications? What might be the unintended consequences? And how could we share our progress in a responsible way? 
This presented a wide range of opportunities and risks to consider, many of which were in areas where we didn’t necessarily have strong expertise. So we sought out external input from over 30 field leaders across biology research, biosecurity, bioethics, human rights, and more, with a focus on diversity of expertise and background.
Many consistent themes came up throughout these discussions:


Based on the input above, the IRC endorsed a set of AlphaFold releases to address multiple needs, including:
Since our initial release, hundreds of thousands of people from over 190 countries have visited the AlphaFold Protein Structure Database and used the AlphaFold open source code since launch. We’ve been honoured to hear of ways in which AlphaFold’s predictions have accelerated important scientific efforts and are working to tell some of these stories with our Unfolded project. So far, we’re not aware of any misuse or harm related to AlphaFold, though we continue to pay close attention to this. 
While AlphaFold was more complex than most DeepMind research projects, we’re using elements of what we’ve learned and incorporating this into other releases.
We’re building upon this work by:
Just like our research, this is a process of continual learning. The development of AI for widespread benefit is a community effort that spans far beyond DeepMind.
We’re making every effort to be mindful of how much hard work there still is to do in partnership with others – and how we pioneer responsibly going forward.

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Note that any programming tips and code writing requires some knowledge of computer programming. Please, be careful if you do not know what you are doing…

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